Fertilizer - Synthetic vs. Natural

Quick question for the group - Fertilizer.  Apart from not being
"green", as is the current fad, are there any long term detrimental
effects that the the modern day synthetic fertilizers may cause to
rose bushes?  I am specifically asking about the Bayer Systemic 2-in-1
fertilizer that protects from bug damage etc.

The reason I bring this up is I was recently told by a mail-order rose
company that I am in effect reducing the life expectancy of the roses
using that type of fertilizer.  I am not sure if I necessarily believe
that since the product is fairly recent.  Also, the concept of green
gardening is something I practice for my vegetables since I will
ingest them, but since the roses are just for looking good, I am less
concerned about the environmentalist pressures that are ever present.

Thoughts?  Opinions?